Table 2

Association analysis of eight cystolic aldehyde dehydrogenase (ALDH1A1) polymorphisms with AUDIT score

Variant

Chromosomal location (bp)a

Gene location

Allelesb

MAFc

Allelic AUDIT score meansd

Genotypic AUDIT score meanse

Genotypic association (p value)

Mode of inheritance


Allele 1

Allele 2

Allele 1

Allele 2

1/1

1/2

2/2

Generalf

Best modelg


rs348479

74702120

3' UTR

G

T

0.177

17.79

19.66

11.00

19.47

19.33

0.08

0.025

Dominant


rs348472

74710880

Intron 1 1

A

G

0.035

20.67

19.30

28.00

18.90

19.08

0.75

0.44

Dominant


rs610529

74723144

Intron 8

A

G

0.399

20.21

17.85

20.50

19.07

14.65

0.027

0.013

Recessive


rs2288087

74733858

Intron 4

A

T

0.475

18.94

19.71

17.53

19.61

19.34

0.48

0.23

Dominant


rs13959

74735702

Exon 3

A

G

0.472

19.65

19.00

19.34

19.48

17.83

0.62

0.33

Recessive


rs348449

74744802

Intron 2

A

G

0.033

19.18

24.20

18.78

24.44

22.00

0.13

0.043

Dominant


rs595958

74750694

Intron 1

C

T

0.354

19.52

19.01

19.19

19.70

17.44

0.53

0.28

Recessive


rs918836

74777539

5' UTR

C

G

0.278

19.03

19.48

18.87

18.79

19.38

0.91

0.66

Recessive


Abbreviations: AUDIT, Alcohol Use Disorder Identification Test; MAF, minor allele frequency.

abp = base-pair position on NCBI dbSNP Build 128.

bThe allele with the lowest frequency is italicised.

cMinor allele frequency of the italicised allele in the volunteers from the general population (n = 201).

dAllelic AUDIT score means were calculated in Qtphase17.

eGenotypic AUDIT score means were calculated in SAS (SAS Institute, version 8.0, Cary, NC) using a general test of association.

fProbability for general association between each SNP and the AUDIT score using analysis of variance models.

gLowest probability of association assuming a genetic mode of inheritance (given in Table) with respect to allele 2.

Lind et al. Human Genomics 2008 3:24-35   doi:10.1186/1479-7364-3-1-24

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