Table 3

Genotypic and allelic analysis of the ALDH1A1 rs348479, rs6l0529 and rs348449 polymorphisms in Finnish controls, problem drinkers and clinically treated alcoholic subjects

SNPa and groupb

Number

Group mean AUDIT score

MAF (%)

Genotype

Genotypic

Allelic


p-valuec

OR (95% Cl)d

p valuec

OR (95% Cl)d


rs348479

GG

GT

TT

(TT and TG) vs GG


controls

105

6.26

18.1

6.7

22.9

70.4

Ref

Ref

Ref

Ref


problem

64

28.27

18.0

3.1

29.7

67.2

0.4

1.01 (0.57-1.79)

1.0

1.01 (0.57-1.79)


alcoholic

104

27.74

14.9

0

29.8

70.2

0.019

N/A

0.4

1.26 (0.75-2.12)


rs610529

AA

AG

GG

GG vs (GA and AA)


controls

105

6.26

39.5

37.1

46.7

16.2

Ref

Ref

Ref

Ref


problem

64

28.27

37.5

35.9

53.1

10.9

0.6

0.92 (0.58-1.44)

0.7

0.92 (0.58-1.44)


alcoholic

104

27.74

29.8

46.1

48.1

5.8

0.045

0.32 (0.12-0.84)

0.040

0.65 (0.43-0.98)


rs348449

AA

AG

GG

AA vs (AG and GG)


controls

105

6.26

1.0

98.1

1.9

0

Ref

Ref

Ref

Ref


problem

64

28.27

7.0

87.5

10.9

1.6

0.017

7.36 (1.51-35.84)

0.003

7.87 (1.67-37.01)


alcoholic

104

27.74

3.4

93.3

6.7

0

0.09

3.72 (0.75-18.33)

0.1

3.62 (0.74-17.64)


aThe population (n = 305) SNP allele frequencies are as follows: rs348479 G allele frequency = 0.17, rs610529 G allele frequency = 0.37 and rs348449 G allele frequency = 0.03.

bThe three groups are: (1) Controls (AUDIT score ≤ 12); (2) Problem drinkers (AUDIT score ≥20, not treated for alcoholism); and (3) Clinically treated alcoholics.

cGenotype and allele distributions of the problem drinkers and treated alcoholic subjects were each compared with those in the control group using two-sided Pearson's chi-square or Fisher exact tests, respectively.

dOdds ratios (OR) and Wald 95% confidence intervals (95% CI) were determined separately for the allele and genotype counts of problem drinkers and treated alcoholic subjects versus control drinkers. Genotype odds ratios for each SNP were calculated as follows: rs348479 (GG versus [GT and TT]), rs6l0529 ([AA and AG] versus GG) and rs348449 (AA versus [AG and GG]).

Abbreviations: MAF, minor allele frequency; N/A, not applicable; Ref, reference group.

Lind et al. Human Genomics 2008 3:24-35   doi:10.1186/1479-7364-3-1-24

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