In-silico human genomics with GeneCards
1 Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel
2 Emergentec Biodevelopment GmbH, Vienna, Austria
3 Institute for Theoretical Chemistry, University of Vienna, Vienna, Austria
4 Seattle Children's Research Institute at the Seattle Children's Hospital, and Informatics Department, School of Medicine, University of Washington, Seattle, WA 98101, USA
5 Department of Biological Services, Weizmann Institute of Science, Rehovot, 76100, Israel
Human Genomics 2011, 5:709-717 doi:10.1186/1479-7364-5-6-709Published: 1 October 2011
Since 1998, the bioinformatics, systems biology, genomics and medical communities have enjoyed a synergistic relationship with the GeneCards database of human genes (http://www.genecards.org webcite). This human gene compendium was created to help to introduce order into the increasing chaos of information flow. As a consequence of viewing details and deep links related to specific genes, users have often requested enhanced capabilities, such that, over time, GeneCards has blossomed into a suite of tools (including GeneDecks, GeneALaCart, GeneLoc, GeneNote and GeneAnnot) for a variety of analyses of both single human genes and sets thereof. In this paper, we focus on inhouse and external research activities which have been enabled, enhanced, complemented and, in some cases, motivated by GeneCards. In turn, such interactions have often inspired and propelled improvements in GeneCards. We describe here the evolution and architecture of this project, including examples of synergistic applications in diverse areas such as synthetic lethality in cancer, the annotation of genetic variations in disease, omics integration in a systems biology approach to kidney disease, and bioinformatics tools.