Email updates

Keep up to date with the latest news and content from Human Genomics and BioMed Central.

Open Access Review

GWIDD: a comprehensive resource for genome-wide structural modeling of protein-protein interactions

Petras J Kundrotas1, Zhengwei Zhu13 and Ilya A Vakser12*

Author Affiliations

1 Center for Bioinformatics, The University of Kansas, 2030 Becker Dr., Lawrence, KS, 66047, USA

2 Department of Molecular Biosciences, The University of Kansas, 2030 Becker Dr., Lawrence, KS, 66047, USA

3 Current address: Department of Genetics, Room 716B, Abramson Research Center, University of Pennsylvania, 3615 Civic Center Blvd., Philadelphia, PA, 19104, USA

For all author emails, please log on.

Human Genomics 2012, 6:7  doi:10.1186/1479-7364-6-7

Published: 11 July 2012

Abstract

Protein-protein interactions are a key component of life processes. The knowledge of the three-dimensional structure of these interactions is important for understanding protein function. Genome-Wide Docking Database (http://gwidd.bioinformatics.ku.edu webcite) offers an extensive source of data for structural studies of protein-protein complexes on genome scale. The current release of the database combines the available experimental data on the structure and characteristics of protein interactions with structural modeling of protein complexes for 771 organisms spanned over the entire universe of life from viruses to humans. The interactions are stored in a relational database with user-friendly interface that includes various search options. The search results can be interactively previewed; the structures, downloaded, along with the interaction characteristics.

Keywords:
Protein-protein interactions; Structural modeling; Protein docking; Structural genomics; Interactome