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Softwares and methods for estimating genetic ancestry in human populations

Yushi Liu1, Toru Nyunoya12, Shuguang Leng1, Steven A Belinsky1, Yohannes Tesfaigzi1 and Shannon Bruse1*

Author Affiliations

1 Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. S.E, Albuquerque, NM, 87108, USA

2 VA Medical Center, Albuquerque, NM, USA

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Human Genomics 2013, 7:1  doi:10.1186/1479-7364-7-1

Published: 5 January 2013


The estimation of genetic ancestry in human populations has important applications in medical genetic studies. Genetic ancestry is used to control for population stratification in genetic association studies, and is used to understand the genetic basis for ethnic differences in disease susceptibility. In this review, we present an overview of genetic ancestry estimation in human disease studies, followed by a review of popular softwares and methods used for this estimation.

Ancestry; Genetic; Polymorphism; Structure